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mitotane will lessen the level or effect of abemaciclib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of abemaciclib with potent CYP3A4 inducers lessens plasma focus of abemaciclib and its metabolites.Should you have an an infection, or when you are convinced you might be susceptible